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NOTICE TO ALL CUSTOMERS RESIDING IN THE UNITED STATES

Medicina Mexico received an email from the United States Food and Drug Administration.   The laws of the United States require Medicina Mexico to change its policies relating to anyone that resides in the United States.

The changes are not major changes to our customers however, it is in your best interest that we immediately make these changes.

All the medicine sold by Medicina Mexico online is sold over the counter and it does not require a prescription in Mexico.   HOWEVER, The United States does require a prescription.  Consequently, our Mexican MD’s will be issuing prescriptions to our customers that reside in the United States.   It is your duty to keep your phone number and email address up to date always.   Please log into your account at Medicina Mexico and if your phone number, email address or physical address has change then please update it.   If you are in possession of a current prescription written by a Medical Doctor from the States, then please email a copy to:  sales@meds.com.mx along with your order number.

US Law requires all Pharmacies to provide their customers with detailed descriptions in English of all medicines sold including all risks associated with that specific medicine.   As of September 22, 2017, Medicina Mexico will be giving all our US customers that exact same documentation   Until we update our web servers, PLEASE ONLY RELY on the information we give you in writing that is enclosed in your shipment as this is updated and current information.   It is in your best interest that you read and understand the documentation we will be giving to you.   If for any reason you have any questions about the medicine sold to you then please contact a Medical Doctor for advice before taking any medicine.

Medicina Mexico is in the process of setting up a video service that will work with your smart phones where you can contact one of our licensed Medical Doctors.   Our doctors speak English.   To use this new service the doctor will have access to your order number and you will be required to supply your order number and other information. Once this service is setup we highly encourage you to use this service.

All customers residing in the United States will be prohibited from purchasing medications from Medicina Mexico that are not currently approved by the United States Food and Drug Administration.  Over 95% of the medicines we sell are approved in the United States.   If a medicine is not approved, we will of course notify you.
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Because our staff is so busy processing over 155,000 new online orders every day we had to make some tough decisions. We are no longer taking phone calls, or adding shipping information into the web servers. We do answer all emails within 2-3 hours and that will never stop.

All order are shipped within 48 hours of receipt of funds unless we are out of stock on a medicine. We are now informing our customers of orders that are out of stock via email. Please do not send us an email asking if your order has shipped as we are too busy packaging orders and we will not respond unless your order is late per our terms of shipment. We are real busy shipping orders and this is our first priorty. Express and International Express that are late by 5 days we will answer those emails.

Cross-border shipments going through customs inspections can delay delivery. These delays are out of our control as well as the carriers. Over 95% of the deliveries are delivered on time.

Please NOTE: Funds received without an order number are placed into our SUSPENSE ACCOUNT until we are able to determine the correct owner and order number. To avoid this, please always send an email to sales@meds.com.mx along with your order number and the fact that you made a payment.

Licensed pharmacies in Mexico are only allowed to sell medications, either brands or generics, from an approved pharmaceutical which has passed testing and has subsequently been authorized by the Mexican Government.

If you look on the left at About US you will see our licenses, permits and our Regulatory Body.

PLEASE TAKE NOTICE: Our email address is sales@meds.com.mx or meds.com.mx@gmail.com

   
   
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Llurtopin, bromuro de pinaverio 100MG 14 TABS

Llurtopin, bromuro de pinaverio 100MG 14 TABS
Model:LURTOPIN 100
Current Reviews:0
Price:$7.85

LURTOPIN BROMURO DE PINAVERIO 100MG 14 TABS

Each tablet contains:

Pinaverium bromide 100 mg

Excipient, c.b.p. 1 tablet.

THERAPEUTIC INDICATIONS: This is for the treatment of irritable bowel syndrome (IBS) in any of its subtypes, according to the criteria Rome III (constipation predominant, diarrhea-predominant, mixed and unclassifiable), nervous colitis, intestinal colic. This is also indicated in all functional disorders of intestinal motility involving pain and bloating.

Pharmacokinetics IN HUMAN bromide is a calcium antagonist pinaverium different from other conventional types of calcium antagonists, because of its high selectivity for the gastrointestinal smooth muscle, by its dual action mechanism regulating intestinal motility and decreased visceral hypersensitivity . Pinaverium bromide exerts its antispasmodic action of calcium channel blocking voltage-dependent subunit specifically? -1 - And prevents muscle contractions induced by gastrointestinal hormones and mediators such as cholecystokinin (CCK) and substance P. It has also been shown to inhibit the action of serotonin nerve transmission involved in triggering the intestinal contraction. Pinaverium bromide decreases visceral hypersensitivity because it selectively blocks the actions of CCK and substance P in afferent neurons. 

Pinaverium bromide diffuses through the mucosa, specifically to the intestinal smooth muscle without being significantly absorbed systemically. Calcium channel "slow" voltage-gated (VOCs "L") are located on the outer surface of the wall of the gastrointestinal muscle cells, reducing the contraction of isolated smooth muscle cells. Pinaverium bromide is a potent selective affinity to join them, so it blocks the entry of calcium through these channels and prevents contractile activity of the intestine. It has been shown in several in vivo and in vitro effect pinaverium bromide on gastrointestinal contractile activity. Unlike calcium channel antagonists conventional Pinaverium Bromide has no clinically relevant activity outside the gastrointestinal tract.

The affinity and the antagonistic action pinaverium bromide are constant and independent of the conditions for activation or resting the intestinal muscle cell. The records of colon myoelectric two hours before eating and three hours later, showed that the bromide pinaverium suppressed postprandial motor response (gastrocolic reflex). Electromanométricas measurements obtained after mechanical stimulation in patients with intestinal motor disturbances showed that pinaverium bromide significantly decreased the motility index, further reducing the duration that the intensity of contractions. Some authors have reported studies in which balloon catheters used to measure intraluminal pressure variations followed by a test meal. The results indicate that Pinaverium Bromide motility reduces overall sigmoid region and in the colon, without affecting the standard propulsive activity.

The effects of bromide pinaverium on transit time, which is relevant to patients with constipation-predominant IBS, have been investigated in some studies, resulting in decreased transit time compared with placebo (p <0.05), mainly through the descending colon and rectosigmoid. 

Similar results have been reported in patients with colonic disease who suffer from chronic constipation, pinaverium bromide significantly shortened transit time. Studies in patients with diarrhea-predominant IBS do not show increased motility index pinaverium bromide.

The effect of bromide pinaverium to visceral hypersensitivity has been shown because it prevents contractions induced by hormones and mediators as colecistocininas (CCK) and substance P, which are known to be dependent Ca2 + and sensitive to antagonists of Ca2 +. Studies were conducted on isolated smooth muscle cells, previously contracted by hormones, CCK and substance P where the effect was assessed by measuring the length of the cell in both control and treated cells. Under these experimental conditions, pinaverium bromide showed potent activity with an IC50 of approximately 1 nM. This effect was confirmed in vitro in vivo demonstrating that it has effects on visceral sensitivity. In the presence of inflammation, pinaverium bromide significantly reduces the severity of abdominal pain caused by rectal distension without affecting the recto-colonic inhibitory reflex.

One of the most important pharmacokinetic properties possessed by compounds such as quaternary ammonium derivatives Pinaverium Bromide, is their low bioavailability (less than 0.5%).

The little bromide pinaverium absorbed almost all, binds to plasma proteins portosystemic circulation, thus having an excellent and extensive hepatic metabolism with excretion biliofecal through demethylation of the methoxy group, hydroxylation of the ring and eliminating norpinanil benzyl group with subsequent morpholine ring opening. 

The physicochemical characteristics of these compounds, a polar charge permanently activated, allow them to stay in the light of the intestinal tract, thus exerting its action as a muscle relaxant with a topical or local activity practically. The rate of absorption of these compounds through the intestinal mucosa depends basically three ways: passive transport, which is proportional to the concentration of compound in the intestinal lumen, active transport, whose degree of saturation depends on the dose-time, and finally an active secretion system similarly dependent of the dose-time.

The action topical or local pinaverium bromide coupled with selective affinity that this compound has to slow calcium channel "L" voltage-dependent, gives the molecule an effective and normorreguladora spasmolytic activity of intestinal transit, resulting in reducing abdominal pain in 90% of cases (men and women) and over 90% of patients have clinical improvement compared to bloating, constipation, diarrhea, nausea / vomiting.

Hypersensitivity pinaverium bromide.

PRECAUTIONS: None.

Use in Pregnancy and Lactation pinaverium bromide practically not absorbed into the systemic circulation, which makes it unlikely the passage of significant concentrations of the drug into the fetal circulation or breast milk, however, the intake the last trimester of pregnancy may cause hypotonia and sedation in the newborn. The use of this medicine during pregnancy and lactation is the responsibility of the physician.

ADVERSE REACTIONS: In some sensitive people can pinaverium bromide abdominal pain, itching, rash, diarrhea, nausea or dry mouth.

 

   
   
   
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